Zebrafish Genome Biology at CSIR Institute of Genomics and Integrative Biology
Laboratories at CSIR Institute of Genomics and Integrative Biology

Dr. Sridhar Sivasubbu
Sridhar Sivasubbu Lab is interested in developing zebrafish as a model for human biology and disease related processes. His group uses a combination of genetics and genomics tools to decipher gene function and genome organization in vertebrates. His group is interested in understanding:Molecular mechanisms underlying cardiovascular and vascular development & disorder Genome organization and architecture in vertebrates

Dr. Chetana Sachidanandan
Chetana Sachidanandan is interested in Identification of molecular players important for development and disease pathophisiology using a combination of genetic and chemical screens in zebrafish.

Dr. Vinod Scaria
Vinod Scaria is a medico turned computational biologist. His lab analyses zebrafish genome towards understanding parallels in vertebrate genome organisation and regulation and discovering candidate disease genes and regulatory mechanisms in disease processes.

Colaborator labs
Dr. Souvik Maiti
Studying the anatgonostic effect of aminoglycosides on microRNA biogenesis using zebrafish as a model organism.

Zebrafish Genomics Resources at CSIR Institute of Genomics and Integrative Biology
Recent Publications:

Singh M, Bhartiya D, et al.
The Zebrafish GenomeWiki: A crowdsourcing approach to connect the long tail for zebrafish gene annotation
Database (2014) Accepted

Kaushik K, Leonard VE, Shamsudheen KV, Lalwani MK, Jalali S, Patowary A, Joshi A, Scaria V, Sivasubbu S.
PLoS One. 2013 Dec 31;8(12):e83616. doi: 10.1371/journal.pone.0083616.

Sivasubbu S, Sachidanandan C, Scaria V.
Time for the zebrafish ENCODE.
J Genet. 2013 Dec;92(3):695-701.

Patowary A, Purkanti R, Singh M, Chauhan R,Singh AR, Swarnkar M, Singh N, Pandey V, Torroja C, Clark MD, Kocher J, Clark KJ, Stemple DL, Klee EW, Ekker SC*, Scaria V*, Sivasubbu S*
A sequence-based variation map of zebrafish.
Zebrafish. (2013) March 2013, 10(1): 15-20. doi:10.1089/zeb.2012.0848.[Cover Article]

Soni, Kartik; Choudhary, Ashwani; Patowary, Ashok; Singh, Angom; Bhatia, Shipra; Sivasubbu, Sridhar; Chandrasekaran, Shanti; Pillai, Beena.
miR-34 is maternally inherited in Drosophila melanogaster and Danio rerio.
Nucleic Acids Res.(2013) Accepted

Jalali S, Bhartiya D, Lalwani MK, Sivasubbu S*, Scaria V*.
Systematic transcriptome wide analysis of lncRNA-miRNA interactions.
PLoS One. 2013;8(2):e53823

Lalwani MK, Sharma M, Singh AR, Chauhan RK, Patowary A, Singh N, Scaria V*, Sivasubbu S*.
Reverse genetic screen in zebrafish identify role of miR-142a-3p in vascular development and integrity.
PLoS One. 2012;7(12):e52588

Clark KJ, Balciunas D, Pogoda HM, Ding Y, Westcot SE, Bedell VM, Greenwood TM, Urban MD, Skuster KJ, Petzold AM, Ni J, Nielsen AL, Patowary A, Scaria V, Sivasubbu S, Xu X, Hammerschmidt M, Ekker SC.
In vivo protein trapping produces a functional expression codex of the vertebrate proteome.
Nat Methods. June 2011. Vol.8 No.6.506-512

Suryawanshi H, Lalwani MK, Ramsamy Soundhar,Rana R,Scaria V, Sivasubbu S, Maiti S
Antagonism of microRNA function in zebrafish embryos using Locked Nucleic Acid Enzymes(LNAzymes) ChemBioChem, (2012) 13: 584–589.

Bhartiya D, Maini J, Sharma M, Joshi P, Laddha SV, Jalali S, Patowary A, Purkanti R, Lalwani M, Singh AR, Chauhan R, Singh N, Bhardwaj A, Scaria V*, and Sivasubbu S*
FishMap Zv8 Update—A Genomic Regulatory Map of Zebrafish
Zebrafish (2010) Jun;7(2):179-80.

Meli R, Prasad A, Patowary A, Lalwani MK, Maini MK, Sharma M,
Singh AR, Kumar G, Jadhav V, Scaria V*, Sivasubbu S.
FishMap: A community resource for Zebrafish genomics.
Zebrafish June 1, 2008, 5(2): 125-130 [Cover Article]